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28-07-2017 / Publication de notre travail sur l'incidence de l'AHAI pédiatrique en Aquitaine

Nous somme heureux d'annoncer la publication de notre travail sur l'incidence de l'AHAI en Aquitaine....Pour la premiere fois une évaluation précise de l'incidence de l'AHAI !

Reliable assessment of the incidence of childhood autoimmune hemolytic anemia Pediatr Blood Cancer. 2017 Jul 27. doi: 10.1002/pbc.26683. (Pubmed, site de l'éditeur)

BACKGROUND:
Childhood autoimmune hemolytic anemia (AIHA) is a rare and severe disease characterized by hemolysis and positive direct antiglobulin test (DAT). Few epidemiologic indicators are available for the pediatric population. The objective of our study was to reliably estimate the number of AIHA cases in the French Aquitaine region and the incidence of AIHA in patients under 18 years old.
PROCEDURE:
In this retrospective study, the capture-recapture method and log-linear model were used for the period 2000-2008 in the Aquitaine region from the following three data sources for the diagnosis of AIHA: the OBS'CEREVANCE database cohort, positive DAT collected from the regional blood bank database, and the French medico-economic information system.
RESULTS:
A list of 281 different patients was obtained after cross-matching the three databases; 44 AIHA cases were identified in the period 2000-2008; and the total number of cases was estimated to be 48 (95% confidence interval [CI]: 45-55). The calculated incidence of the disease was 0.81/100,000 children under 18 years old per year (95% CI 0.76-0.92).
CONCLUSION:
Accurate methods are required for estimating the incidence of AIHA in children. Capture-recapture analysis corrects underreporting and provides optimal completeness. This study highlights a possible under diagnosis of this potentially severe disease in various pediatric settings. AIHA incidence may now be compared with the incidences of other hematological diseases and used for clinical or research purposes.

ACTUALITÉS


Publication de notre travail sur l'incidence de l'AHAI pédiatrique en Aquitaine

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BIBLIOGRAPHICA 5
Veille bibliographique sur les cytopénies auto-immunes de l'enfant...mais pas que!
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